- Laurie A. Sinclair
- Malcolm Sinclair
- Ronald Sinclair
- Sabine Singh
- Tarsem Singh
- Isaac C. Singleton Jr.
- Tony Sirico
- Joseph Sirola
- Kristina Sisco
- Greg Sestero
- Stephen J.M. Sisk
- Gene Siskel
- Tomer Sisley
- Ramon Sison
- Rob Sitch
- Lilia Skala
- Rachel Skarsten
- Red Skelton
- Patricia Skeriotis
- Jason Sklar
- Caroline Lesley
- Jennifer Sky
- Brian Slack
- Jeremy Slate
- Max Elliott Slade
- Daniel Sladek
- Mary Jo Slater
- Brittany Slattery
- Amy Sloan
- Tina Sloan
- Craig Slocum
- Joey Slotnick
- Georgia Slowe
- Peter Marx (II)
- Tucker Smallwood
- Apollo Smile
- Matthew Smiley
- Tava Smiley
- Adrienne Smith
- Alexis Smith
- Allison Smith
- Amber Smith
- Brady Smith
- Brandon Smith
- Brandon Smith (IV)
- Brooke Smith
- Carter B. Smith
- Danny Smith
- Mos Def
- David Lee Smith
- Douglas Smith (VI)
- Dylan Smith (III)
- Eric Smith (VII)
- Eric Smith-Gunn
- Eugene Smith
- Geraldine Smith
- Gregory Smith
- Herbert Smith
- Iain Smith
- Jacob Smith
- James Aaron (II)
- Jim B. Smith
- Jason Matthew Smith
- Kavan Smith
- Kevin Max
- Kim Smith (VII)
- Lane Smith
- Lauren Lee Smith
- Liz Smith (II)
- Lois Smith
- Michael Bailey Smith
- Riley Smith
- S.W. Smith
- Shawnee Smith
- Symba Smith
- Tucker Smith
- Yeardley Smith
- William Smithers
- Bill Smitrovich
- Jurnee Smollett
- Alexandra Smothers
- Stephen Snedden
- Anthony Snow
- Brittany Snow
- William Snow
- David L. Snyder
- Susan Marie Snyder
- Kurt E. Soderling
- Rena Sofer
- André Sogliuzzo
- Chris Solari
- Daniel Sollinger
- Keith Solomon
- Courtney Solomon
- Frances-Anne Solomon
- Ian Somerhalder
- Bonnie Somerville
- Sara Sommerfeld
- Brenda Song
- Manoj Sood
- Veena Sood
- Monty Sopp
- Louise Sorel
- Aaron Sorkin
- Aarne Soro
- Roberto Sosa
- Shannyn Sossamon
- Paul Soter
- Ann Sothern
- Dan Southworth
- Rebecca Callard
- Scott Sowers
- Osman Soykut
- Yvonne Sciò
- Radim Spacek
- Merrie Spaeth
- Gabriel Spahiu
- Ryan Spahn
- Douglas Spain
- Donna Spangler
- Gabriela Spanic
- Joe Spano
- David Sparrow
- Aaron D. Spears
- Corey Spears
- Eddie Spears
- Michael Spears
- Matt Spease
- Phil Spector
- Carol Speed
- Ken Speed
- Richard Speight Jr.
- Sebastian Spence
- Abigail Spencer
- Brad Spencer
- C.B. Spencer
- Danielle Spencer (II)
- Jesse Spencer
- John Spencer
- Lee Spencer
- Tara Spencer-Nairn
- Wendie Jo Sperber
- Melodee Spevack
- Spice Williams
- Howard Spiegel
- Robert Spillane
- Daniel Spink
- J.C. Spink
- Jordana Spiro
- Angelo Spizzirri
- Michael Spound
- Cole Sprouse
- Dylan Sprouse
- Eric Spudic
- Enzo Squillino Jr.
- Jerry Sroka
- Steven St. Croix
- Soledad St. Hilaire
- Jasmin St. Claire
- Dennis St John
- Marco St. John
- Trevor St. John
- Stuart St. Paul
- Rebecca Staab
- Nick Stabile
- Ben Stacey
- Robert Stack
- Timothy Stack
- Michelle Stafford
- Evan Stafford
- Susan Stafford
- Jeffrey Byron
- Jewel Staite
- Frank Stallone
- Jackie Stallone
- Sage Stallone
- Josh Stamberg
- Lauren Stamile
- Aaron Stanford
- BernNadette Stanis
- Ezra Stanley
- Kim Stanley
- Mike Stanley
- Shane Stanley
- Christopher Stanton
- Molly Stanton
- Christopher Stapleton
- Jacinta Stapleton
- Jean Stapleton
- Maureen Stapleton
- Oliver Stapleton
- Anthony Starke
- Martin Starr
- Mike Starr
- Ringo Starr
- Todd Stashwick
- Kevin Alexander Stea
- Kate Steavenson-Payne
- Peter Stebbings
- Jennifer Steede
- Johanna ter Steege
- Christine Steel
- Brian Steele
- Jennifer Steele
- Jessica Steen
- Nikolaj Steen
- Paprika Steen
- Yvette Nelson
- Jack Stehlin
- Ben Stein
- Mary Stein
- David Steinberg
- Robert Martin Steinberg
- Mark Steines
- Richard Steinmetz
- Nadine Stenovitch
- Andreas Stenschke
- Darryl Stephens
- Janaya Stephens
- Sheila MacRae
- Ania Stepien
- Amanda Stepto
- Andrei Sterling
- Ketzal Sterling
- Mindy Sterling
- Jenna Stern
- Steve-O
- Carrie Stevens
- Dennis F. Stevens
- George Stevens
- Inger Stevens
- Michael Stevens (IV)
- Naomi Stevens
- Roderick E. Stevens
- Rosemary Gore
- Wass Stevens
- Ray Stevenson
- Amy Stewart (II)
- Catherine Mary Stewart
- Charlotte Stewart
- French Stewart
- Joey Stewart
- Jon Stewart
- Kristen Stewart
- Paula Stewart
- Sara Stewart
- Sarah Stewart
- Sylvia Stewart
- Will Stewart
- Phyllis Yvonne Stickney